![]() ![]() Mash DC, Duque L, Page B, Allen-Ferdinand K. Efficacy of ketamine in the treatment of substance use disorders: a systematic review. Jones JL, Mateus CF, Malcolm RJ, Brady KT, Back SE. Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction. Johnson MW, Garcia-Romeu A, Cosimano MP, Griffiths RR. Pilot study of responsive nucleus accumbens deep brain stimulation for loss-of-control eating. Shivacharan RS, Rolle CE, Barbosa DAN, Cunningham TN, Feng A, Johnson ND, et al. Closed-loop neuromodulation in an individual with treatment-resistant depression. Scangos KW, Khambhati AN, Daly PM, Makhoul GS, Sugrue LP, Zamanian H, et al. Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. O’Reardon JP, Solvason HB, Janicak PG, Sampson S, Isenberg KE, Nahas Z, et al. Efficacy and safety of AXS-05 (dextromethorphan-bupropion) in patients with major depressive disorder: a phase 3 randomized clinical trial (GEMINI). Iosifescu DV, Jones A, O’Gorman C, Streicher C, Feliz S, Fava M, et al. Trial of SAGE-217 in patients with major depressive disorder. Gunduz-Bruce H, Silber C, Kaul I, Rothschild AJ, Riesenberg R, Sankoh AJ, et al. Single-dose psilocybin for a treatment-resistant episode of major depression. Goodwin GM, Aaronson ST, Alvarez O, Arden PC, Baker A, Bennett JC, et al. MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study. Mitchell JM, Bogenschutz M, Lilienstein A, Harrison C, Kleiman S, Parker-Guilbert K, et al. Repetitive transcranial magnetic stimulation for smoking cessation: a pivotal multicenter double-blind randomized controlled trial. Zangen A, Moshe H, Martinez D, Barnea-Ygael N, Vapnik T, Bystritsky A, et al. ![]() Deep brain stimulation of the nucleus accumbens in treatment-resistant alcohol use disorder: a double-blind randomized controlled multi-center trial. 2022 19:1229–45.īach P, Luderer M, Müller UJ, Jakobs M, Baldermann JC, Voges J, et al. 2016 16:1–66.įigee M, Riva-Posse P, Choi KS, Bederson L, Mayberg HS, Kopell BH. Repetitive transcranial magnetic stimulation for treatment-resistant depression: a systematic review and meta-analysis of randomized controlled trials. Gaynes BN, Lloyd SW, Lux L, Gartlehner G, Hansen RA, Brode S, et al. Stanford accelerated intelligent neuromodulation therapy for treatment-resistant depression. 2018 41:341–53.Ĭole EJ, Stimpson KH, Bentzley BS, Gulser M, Cherian K, Tischler C, et al. Electroconvulsive therapy in depression: current practice and future direction. Hermida AP, Glass OM, Shafi H, McDonald WM. Damage to the insula disrupts addiction to cigarette smoking. Naqvi NH, Rudrauf D, Damasio H, Bechara A. Brexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial. Kanes S, Colquhoun H, Gunduz-Bruce H, Raines S, Arnold R, Schacterle A, et al. Ketamine treatment for depression: a review. Yavi M, Lee H, Henter ID, Park LT, Zarate CA Jr. Rapid effects of deep brain stimulation for treatment-resistant major depression. Schlaepfer TE, Bewernick BH, Kayser S, Madler B, Coenen VA. Is there a delay in the onset of the antidepressant effect of electroconvulsive therapy? Br J Psychiatry. Deep brain stimulation for treatment-resistant depression. Mayberg HS, Lozano AM, Voon V, McNeely HE, Seminowicz D, Hamani C, et al. Differential time course of antidepressant effects after sleep deprivation, ECT, and carbamazepine: clinical and theoretical implications. Similarly, evidence that stroke lesions in specific brain regions have been associated with immediate and long-lasting resolution of drug craving is indicative for the possibility of immediate symptom resolution in addiction. And ketamine, esketamine and brexanolone have each demonstrated the potential to resolve depressive symptoms and suicidality in hours. Neurostimulation can sometimes bring about rapid (within days) or ultra-rapid (minutes to hours) improvement in patients with major depressive disorder or obsessive-compulsive disorder. ![]() Depression, for example, can resolve immediately after prolonged sleep deprivation (only to recur equally immediately after a nap). Yet this assumption is unmerited, as evidenced by numerous rigorous demonstrations of rapid symptom resolution following a variety of interventions. This simple fact has caused many to assume that rapid-onset therapeutics are impossible that resolution of complex mood, behavioral and cognitive symptoms unavoidably takes time. The vast majority of drugs for psychiatric and substance use disorders take many days or weeks to work. ![]()
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